• Histologically proven initial diagnosis of prostate adenocarcinoma

• Priory treated and controlled primary tumor

• Biochemical recurrence defined by prostate-specific antigen (PSA) values \>0,2 ng/ml (i.e., two consecutive increases) following radical prostatectomy + postoperative radiotherapy and a PSA value of 2 ng/ml above the nadir after high-dose RT.

• Oligorecurrent disease defined as a maximum of 5 extracranial metastases in any organ, diagnosed on PSMA PET-CT or PSMA PET-MRI reported according to the E-PSMA consensus guidelines for interpretation of PSMA-PET (26). Nodal (N1) disease can be included only when accompanied by M1a-c disease, provided that the total number of spots does not exceed 5.

• Serum testosterone level within normal range.

• WHO performance 0-2

• Age \>= 18 years old

• Absence of psychological, sociological or geographical condition potentially hampering compliance with study protocol.

• Patients must be presented at the multidisciplinary board meeting and the inclusion in the trial needs approval by this board.

• Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures

• 2\. Use of highly effective methods of birth control; defined as those that, alone or in combination, result in low failure rate (i.e., less than 1% per year) when used consistently and correctly; such as implants, injectables, combined oral contraceptives, some IUDs, true sexual abstinence (i.e. refraining from heterosexual intercourse during the entire period of risk associated with the Trial treatment(s)) or commitment to a vasectomised partner.